The Big 5 Autoimmune Diseases
SLE vs RA vs Scleroderma vs Dermatomyositis vs Sjogren's. Battle cards, antibody matching game, diagnostic decision tree, 10-question quiz pool.
Autoantibodies: Disease Associations & Drug-Induced Lupus
Hypersensitivity Reactions (Types I-IV)
Types I-IV, IgE vs IgG vs T-cells, timing, classic diseases, board traps. Drag-drop type sorter + elimination game + 12-question pool.
Type I Hypersensitivity Effector Axis
Allergen Immunotherapy and Blocking IgG4
Primary Immunodeficiency Disorders
The Big 10: Bruton's, SCID, DiGeorge, CGD, Wiskott-Aldrich, CVID, Hyper-IgM, Chediak-Higashi, IgA deficiency, complement. Disease cards, drag-drop sorting, decision tree, elimination game + 14-question pool.
Vasculitis: read the vessel before naming the disease
Localize vessel size, organ pattern, pathology, and immune context to distinguish major vasculitides and choose the next diagnostic or treatment step.
Free Radicals and the Phagocyte Respiratory Burst
Classify reactive oxygen species, trace the phagocyte respiratory burst, and distinguish CGD from MPO and G6PD defects on board-style cases.
Complement: surfaces, amplification and protection
Follow three complement starts through surface amplification, host protection, immune clearance and clinical pathway tests, with accessible mechanism diagrams and cases.
Complement Deficiencies: Locate the Break and the Overactive Brake
Use pathway tests, timing and tissue findings to distinguish missing complement defense from runaway activation in infection, swelling, blood and kidney disease.
Immune Cell Lineage: Read the Blood Family Tree
Trace blood cells from hematopoietic stem cells, distinguish myeloid from lymphoid patterns, read key markers and smears, and avoid lineage traps.
The Lymphatic System: Organs, Histology and Drainage
Anaphylaxis
IgE mast-cell release, IM epinephrine first, and the biphasic trap.
Antibody Structure and the Germinal Center
Interferons: signal, response and antiviral defense
Trace interferon production, receptor signaling and antiviral effectors; use controlled comparisons to separate a missing alarm from a failed response.
Transplant Rejection
T-Cell Costimulation, Immune Tolerance and Checkpoints
Distinguish recognition, costimulation, anergy, deletion, and regulation, then predict checkpoint drug effects and interpret immune toxicity in clinical cases.